do with

do with
处理；利用
He has to do with all sorts of people.
他得和各种各样的人打交道。
I have a huge pile of letters to do with.
我有一大堆信件要处理。
Firstly, let us do with the most important issue.
首先让我们来处理最紧要的问题。
What do I do with the documents and the information?
我怎么处理这些文件和资料？
What do you do with my pocket knife?
你用我的小刀做什么了？

详解：

do with 常与连接代词 what 连用，而 deal with 常与连接副词 how 连用，如：
1 . I don’t know how they deal with the problem . (= I don‘t know what they do with the problem . )
我不知道他们如何处理这个问题。
2 . He is easy to deal with . (= He is easy to do with . 这时“do”是不及物动词)他是容易相处的人。这两个词组在使用时有细微的差别。一般地说，do with 表示“处置”、“忍受”、“相处”、“有关”等。如：
1 . They found a way to do with the elephant .
他们找到对付那头大象的办法了。
2 . We can’t do with such carelessness .
我们不能容忍这种粗枝大叶的作风。
3 . We are difficult to do with the new comer .
我们很难与新来的那个人相处。
4 . I have nothing to do with him .
我跟他无任何关系。
deal with 意义很广，常表示“对付”、“应付”、“处理”、“安排”、“论述”、“涉及”等。如：
1 . They could properly deal with all kinds of situations .
他能恰当地应付各种局面。
2 . Deal with a man as he deals with you .
以其人之道，还治其人之身。
3 . This is a book dealing with Asian problems .
这是一本论述亚洲问题的书。
4 . They have learned to deal with various persons .
他们学会了和各种人打交道。

depend on (upon)<-->die out